Fractional White Smell Agent Optimization for CNN-Based Transfer Learning in Melanoma Classification
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Melanoma is the deadliest form of skin cancer, and early diagnosis and treatment can significantly reduce mortality rates. However, existing strategies for classifying melanoma from dermoscopic skin images still face significant challenges. Therefore, this study aims to develop an accurate method for melanoma classification using dermoscopic skin images. A novel melanoma classification framework, termed Fractional White Smell Agent Optimization-enabled Convolutional Neural Network-based Transfer Learning (FWSAO_CNN-based TL), is proposed. First, the input skin image is preprocessed using an Adaptive Kalman Filter. Subsequently, skin lesion segmentation is performed using LinkNet, where the network is trained using White Smell Agent Optimization (WSAO). Following segmentation, image augmentation is applied, and feature extraction is conducted. Finally, melanoma classification is performed using a CNN-based transfer learning model trained with the proposed Fractional White Smell Agent Optimization (FWSAO), which integrates the Fractional concept, Smell Agent Optimization (SAO), and White Shark Optimizer (WSO). The CNN utilizes hyperparameters derived from a pretrained GoogLeNet model. The performance of the proposed FWSAO_CNN-based TL framework was evaluated using accuracy, True Positive Rate (TPR), and True Negative Rate (TNR). The proposed method achieved values of 91.565%, 90.090%, and 91.269%, respectively. Furthermore, the proposed model demonstrated performance improvements of 18.4%, 8.1%, 17.5%, 12.55%, 8.2%, and 6.23% compared with conventional approaches.
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[1] Haque, Intisar Rizwan I., and Jeremiah Neubert. "Deep learning approaches to biomedical image segmentation." Informatics in Medicine Unlocked 18 (2020): 100297. doi:10.1016/j.imu.2020.100297.
[2] Vijaya, P. (2023). Adaptive jellyfish search optimization trained deep learning for breast cancer classification using histopathological images. Mapana Journal of Sciences, 22(3), 59. doi:10.12723/mjs.66.3.
[3] Goyal, M., Oakley, A., Bansal, P., Dancey, D., & Yap, M. H. (2020). Skin Lesion Segmentation in Dermoscopic Images with Ensemble Deep Learning Methods. IEEE Access, 8, 4171–4181. doi:10.1109/ACCESS.2019.2960504.
[4] Breeze, S., Peterson, C., Garioch, J., Nobes, J., & Moncrieff, M. (2025). A Simplified Classification System for In-Transit Melanoma Metastases. Annals of Surgical Oncology, 33(3), 2579–2590. doi:10.1245/s10434-025-18542-9.
[5] Loganathan, G. B., Hamadamen, N. I., Yasin, E. T., Yasin, A. T., Mohammad, A. A., Adil, I. N., ... & Hamadameen, S. F. (2022). Melanoma classification using enhanced fuzzy clustering and DCNN on dermoscopy images. NeuroQuantology, 12, 196-213.
[6] Shorfuzzaman, M. (2022). An explainable stacked ensemble of deep learning models for improved melanoma skin cancer detection. Multimedia Systems, 28(4), 1309–1323. doi:10.1007/s00530-021-00787-5.
[7] Ding, J., Song, J., Li, J., Tang, J., & Guo, F. (2022). Two-Stage Deep Neural Network via Ensemble Learning for Melanoma Classification. Frontiers in Bioengineering and Biotechnology, 9, 1355. doi:10.3389/fbioe.2021.758495.
[8] Aksoy, S. (2025). Multi-Input Melanoma Classification Using Mobilenet-V3-Large Architecture. Journal of Automation, Mobile Robotics and Intelligent Systems, 19(1), 73–84. doi:10.14313/jamris-2025-008.
[9] Kaur, R., Gholamhosseini, H., Sinha, R., & Lindén, M. (2022). Melanoma Classification Using a Novel Deep Convolutional Neural Network with Dermoscopic Images. Sensors, 22(3), 1134. doi:10.3390/s22031134.
[10] Ghosh, S., Singh, A., & Kumar, S. (2025). Multiplier leadership optimization algorithm (MLOA): unconstrained global optimization approach for melanoma classification. Discover Internet of Things, 5(1). doi:10.1007/s43926-025-00168-8.
[11] Aljohani, K., & Turki, T. (2022). Automatic Classification of Melanoma Skin Cancer with Deep Convolutional Neural Networks. AI (Switzerland), 3(2), 512–525. doi:10.3390/ai3020029.
[12] Broekaert, S. M. C., Roy, R., Okamoto, I., Van Den Oord, J., Bauer, J., Garbe, C., Barnhill, R. L., Busam, K. J., Cochran, A. J., Cook, M. G., Elder, D. E., McCarthy, S. W., Mihm, M. C., Schadendorf, D., Scolyer, R. A., Spatz, A., & Bastian, B. C. (2010). Genetic and morphologic features for melanoma classification. Pigment Cell & Melanoma Research, 23(6), 763–770. doi:10.1111/j.1755-148X.2010.00778.x.
[13] Salma, W., & Eltrass, A. S. (2022). Automated deep learning approach for classification of malignant melanoma and benign skin lesions. Multimedia Tools and Applications, 81(22), 32643–32660. doi:10.1007/s11042-022-13081-x.
[14] Bhimavarapu, U., & Battineni, G. (2022). Skin Lesion Analysis for Melanoma Detection Using the Novel Deep Learning Model Fuzzy GC-SCNN. Healthcare (Switzerland), 10(5), 962. doi:10.3390/healthcare10050962.
[15] Qureshi, M. N., Umar, M. S., & Shahab, S. (2022). A Transfer-Learning-Based Novel Convolution Neural Network for Melanoma Classification. Computers, 11(5), 64. doi:10.3390/computers11050064.
[16] Garcia, A., Zhou, J., Pinero-Crespo, G., Beachkofsky, T., & Huang, X. (2025). Clinical Application of Vision Transformers for Melanoma Classification: A Multi-Dataset Evaluation Study. Cancers, 17(21), 3447. doi:10.3390/cancers17213447.
[17] Manikandan, S. P., Narani, S. R., Karthikeyan, S., & Mohankumar, N. (2025). Deep learning for skin melanoma classification using dermoscopic images in different color spaces. International Journal of Electrical and Computer Engineering, 15(1), 319. doi:10.11591/ijece.v15i1.pp319-327.
[18] Kaggle. (2019). Skin Lesion Images for Melanoma Classification dataset. Kaggle, San Francisco, United States. Available online: https://www.kaggle.com/datasets/andrewmvd/isic-2019 (accessed on May 2026).
[19] Rutan, S. C. (1991). Adaptive Kalman Filtering. Analytical Chemistry, 63(22), 1103A-1109A. doi:10.1021/ac00022a002.
[20] Chaurasia, A., & Culurciello, E. (2017). LinkNet: Exploiting encoder representations for efficient semantic segmentation. 2017 IEEE Visual Communications and Image Processing (VCIP), 1–4. doi:10.1109/VCIP.2017.8305148.
[21] Salawudeen, A. T., Mu’azu, M. B., Sha’aban, Y. A., & Adedokun, E. A. (2019). on the Development of a Novel Smell Agent Optimization (Sao) for Optimization Problems. I-Manager’s Journal on Pattern Recognition, 5(4), 13. doi:10.26634/jpr.5.4.15677.
[22] Braik, M., Hammouri, A., Atwan, J., Al-Betar, M. A., & Awadallah, M. A. (2022). White Shark Optimizer: A novel bio-inspired meta-heuristic algorithm for global optimization problems. Knowledge-Based Systems, 243, 108457. doi:10.1016/j.knosys.2022.108457.
[23] Khalifa, N. E., Loey, M., & Mirjalili, S. (2022). A comprehensive survey of recent trends in deep learning for digital images augmentation. Artificial Intelligence Review, 55(3), 2351–2377. doi:10.1007/s10462-021-10066-4.
[24] Shorten, C., & Khoshgoftaar, T. M. (2019). A survey on Image Data Augmentation for Deep Learning. Journal of Big Data, 6(1). doi:10.1186/s40537-019-0197-0.
[25] Lessa, V., & Marengoni, M. (2016). Applying Artificial Neural Network for the Classification of Breast Cancer Using Infrared Thermographic Images. Computer Vision and Graphics, ICCVG 2016, Lecture Notes in Computer Science, vol 9972, Springer, Cham, Switzerland. doi:10.1007/978-3-319-46418-3_38.
[26] Mahmood, F. H., & Abbas, W. A. (2016). Texture features analysis using gray level co-occurrence matrix for abnormality detection in chest CT images. Iraqi Journal of Science, 57(1A), 279-288.
[27] Huang, K., Liu, X., Fu, S., Guo, D., & Xu, M. (2021). A Lightweight Privacy-Preserving CNN Feature Extraction Framework for Mobile Sensing. IEEE Transactions on Dependable and Secure Computing, 18(3), 1441–1455. doi:10.1109/TDSC.2019.2913362.
[28] Hany, U., & Akter, L. (2015). Speeded-Up Robust Feature extraction and matching for fingerprint recognition. 2015 International Conference on Electrical Engineering and Information Communication Technology (ICEEICT), 1–7. doi:10.1109/ICEEICT.2015.7307439.
[29] Shi, Z., Hao, H., Zhao, M., Feng, Y., He, L., Wang, Y., & Suzuki, K. (2019). A deep CNN based transfer learning method for false positive reduction. Multimedia Tools and Applications, 78(1), 1017–1033. doi:10.1007/s11042-018-6082-6.
[30] Szegedy, C., Liu, W., Jia, Y., Sermanet, P., Reed, S., Anguelov, D., Erhan, D., Vanhoucke, V., & Rabinovich, A. (2015). Going deeper with convolutions. Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition, 07-12-June-2015, 1–9. doi:10.1109/CVPR.2015.7298594.
[31] Kaggle. (2026). The Melanoma Skin Cancer Dataset of 10000 images. Kaggle, San Francisco, United States. Available online: https://www.kaggle.com/datasets/hasnainjaved/melanoma-skin-cancer-dataset-of-10000-images (accessed on May 2026).
[32] Sharma, M., Monika, Kumar, N., & Kumar, P. (2021). Badminton match outcome prediction model using Naïve Bayes and Feature Weighting technique. Journal of Ambient Intelligence and Humanized Computing, 12(8), 8441–8455. doi:10.1007/s12652-020-02578-8.
[33] Ronneberger, O., Fischer, P., & Brox, T. (2015). U-Net: Convolutional Networks for Biomedical Image Segmentation. Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. MICCAI 2015, Lecture Notes in Computer Science, vol 9351, Springer, Cham, Switzerland. doi:10.1007/978-3-319-24574-4_28.
[34] Zhang, W., Pang, J., Chen, K., & Loy, C. C. (2021). K-Net: Towards Unified Image Segmentation. Advances in Neural Information Processing Systems, 13, 10326–10338.
[35] Michael Mahesh, K., & Arokia Renjit, J. (2020). DeepJoint segmentation for the classification of severity-levels of glioma tumour using multimodal MRI images. IET Image Processing, 14(11), 2541–2552. doi:10.1049/iet-ipr.2018.6682.
[36] Feng, Q., Chen, L., Philip Chen, C. L., & Guo, L. (2020). Deep Fuzzy Clustering-A Representation Learning Approach. IEEE Transactions on Fuzzy Systems, 28(7), 1420–1433. doi:10.1109/TFUZZ.2020.2966173.
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