Studying Properties of Prospective Biologically Active Extracts from Marine Hydrobionts
Biologically active substances (BAS) extracted from marine hydrobionts are characterized by high diversity and efficiency. They are represented by carotenoids, phospholipids, saponins and other compounds possessing high antioxidant (AOA), antitumor, immunomodulatory, radioprotective, and hypolipidemic activities. Because of extremely high marine BAS activity, the BAS dose necessary for treatment and prevention of many diseases is very small. The aim of present work was to assess biological properties of BAS complexes extracted from Black Sea marine inverterbrates for their following using in pharmacological preparations including liposomal drug delivery. BAS complexes were extracted from marine invertebrate tissues by two-phase extraction in combination with ultrasonication. Antioxidant activity of BAS extracts was determined with potassium permanganate discoloration method in an aqueous sulfuric acid medium. Antimicrobial activity was investigated by germination of BAS extracts. BAS influence on lymphocyte proliferative activity was studied with help of cytogenetic analysis. In this paper, the assessment of antioxidant, antimicrobial and mitogenic activities of biologically active complexes extracted from marine invertebrate tissues is presented. BAS properties in the oil and alcohol-water phases are compared. For the first time BAS complexes from Black Sea invertebrates are extracted by the resource-light method of two-phase extraction in combination with ultrasonication. Conditions for obtaining BAS extracts with optimal characteristics are proposed.
Sansone, Clementina, and Christophe Brunet. “Promises and Challenges of Microalgal Antioxidant Production.” Antioxidants 8, no. 7 (June 27, 2019): 199. doi:10.3390/antiox8070199.
Florean, Cristina, Kyung Kim, Michael Schnekenburger, Hyun-Jung Kim, Céline Moriou, Cécile Debitus, Mario Dicato, Ali Al-Mourabit, Byung Han, and Marc Diederich. “Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1’(R), 6’(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.” Marine Drugs 16, no. 12 (December 19, 2018): 518. doi:10.3390/md16120518.
Fouillaud, Mireille, Mekala Venkatachalam, Emmanuelle Girard-Valenciennes, Yanis Caro, and Laurent Dufossé. “Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities.” Marine Drugs 14, no. 4 (March 25, 2016): 64. doi:10.3390/md14040064.
Khotimchenko, Yuri. “Pharmacological Potential of Sea Cucumbers.” International Journal of Molecular Sciences 19, no. 5 (May 2, 2018): 1342. doi:10.3390/ijms19051342.
Sommeng, Andy Noorsaman, R. Muhammad Yusuf Arya, Mikael Januardi Ginting, Diah Kartika Pratami, Heri Hermansyah, Muhamad Sahlan, and Anondho Wijanarko. “Antiretroviral Activity of Pterois Volitans (red Lionfish) Venom in the Early Development of Human Immunodeficiency Virus/acquired Immunodeficiency Syndrome Antiretroviral Alternative Source.” February-2019 12, no. 2 (February 2019): 309–315. doi:10.14202/vetworld.2019.309-315.
Da Mata, Élida Cleyse Gomes, Caroline Barbosa Farias Mourão, Marisa Rangel, and Elisabeth Ferroni Schwartz. “Antiviral Activity of Animal Venom Peptides and Related Compounds.” Journal of Venomous Animals and Toxins Including Tropical Diseases 23, no. 1 (January 6, 2017). doi:10.1186/s40409-016-0089-0.
Loureiro, Daniela R. P., José X. Soares, Joana C. Costa, Álvaro F. Magalhães, Carlos M. G. Azevedo, Madalena M. M. Pinto, and Carlos M. M. Afonso. “Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review.” Molecules 24, no. 2 (January 10, 2019): 243. doi:10.3390/molecules24020243.
Krivoshapko, O. N., A. M. Popov, A. A. Artyukov, and E. Y. Kostetsky. “Peculiarities of the Corrective Effects of Polar Lipids and Bioantioxidants from Sea Hydrobionts in Impairments of Lipid and Carbohydrate Metabolism.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 5, no. 2 (May 24, 2011): 152–157. doi:10.1134/s1990750811020053.
Kozłowska A., D. Szostak-Węgierek. “Flavonoids – Food Sources, Health Benefits, and Mechanisms Involved”. In: Mérillon J.-M., K.G. Ramawat “Bioactive Molecules in Food”. Springer. Cham, 2017. 1-27. doi: 10.1007/978-3-319-54528-8.
Shashkina M.Y., P.N. Shahkin, A.V.Sergeev. “Carotenoids in human health and prevention of diseases”. Russian Biotherapeutical Journal, vol. 9, no 1 (2010): 71-86.
Shashkina M.Y., P.N. Shahkin, A.V.Sergeev. “Carotenoids as a base or cancer chemoprevention”. Russian Biotherapeutical Journal, vol.8, no 4 (2009): 91-98.
Torregrosa-Crespo, Javier, Zaida Montero, Juan Fuentes, Manuel Reig García-Galbis, Inés Garbayo, Carlos Vílchez, and Rosa Martínez-Espinosa. “Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms.” Marine Drugs 16, no. 6 (June 8, 2018): 203. doi:10.3390/md16060203.
Cadenas, E., and L. Packer. Handbook of Antioxidants, 2nd Ed. Marcel Dekker. New York, 2002.
Pawar H.R., S. S. Bhosale, N. D. Derle. “Use of liposomes in cancer therapy: a review”. International Journal of Pharmacological Science and Research, vol. 3, no 10 (2012): 3585-3590. doi:10.13040/IJPSR.0975-8232.3(10).3585-90.
Shubenkova E., O. Chzhu, Y. Lobova, I. Lutayeva. “Study the influence of extraction conditions on elicitation of biologically active substances with antioxidant properties”. Novosibirsk State Pedagogical University Bulletin 3, no 5 (2013): 144-148.
Maksimova T.V., I.N. Nikulina, V.P. Pakhomov, E.I. Shkarina, Z.V. Chumakova, A.P. Arzamastsev. “Method for determining antioxidation activity”. Patent RU2170930C1 (2001).
Hungerford, David A. “Leukocytes Cultured from Small Inocula of Whole Blood and the Preparation of Metaphase Chromosomes by Treatment with Hypotonic KCL.” Stain Technology 40, no. 6 (January 1965): 333–338. doi:10.3109/10520296509116440.
Prarthana, J., and K.R. Maruthi. “Fresh Water Algae as a Potential Source of Bioactive Compounds for Aquaculture and Significance of Solvent System in Extraction of Antimicrobials.” Asian Journal of Scientific Research 12, no. 1 (January 1, 2019): 18–28. doi:10.3923/ajsr.2019.18.28.
Messyasz, Beata, Izabela Michalak, Bogusława Łęska, Grzegorz Schroeder, Bogusława Górka, Karolina Korzeniowska, Jacek Lipok, et al. “Valuable Natural Products from Marine and Freshwater Macroalgae Obtained from Supercritical Fluid Extracts.” Journal of Applied Phycology 30, no. 1 (September 7, 2017): 591–603. doi:10.1007/s10811-017-1257-5.
Azarova O.P. (Chzhu), E.G. Shubenkova, A.K Chernyshev. “Liposomal nanocapsule”. Patent RU2462236C2 (2012).
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